Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
نویسندگان
چکیده
منابع مشابه
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization.
High levels of the plasminogen activators, but also their inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been documented in neovascularization of severe ocular pathologies such as diabetic retinopathy or age-related macular degeneration (AMD). AMD is the primary cause of irreversible photoreceptors loss, and current therapies are limited. PAI-1 has recently been shown to be essentia...
متن کاملDose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials.
PURPOSE To explain the conflicting reports about the influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during the exudative form of age-related macular degeneration. METHODS The expression of PAI-1 mRNA was analyzed in human and murine choroidal neovascularization (CNV) by RT-PCR. The influences of increasing doses of recombinant PAI-1 were e...
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Background: Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein with inhibitory effects on the formation of plasmin from plasminogen by plasminogen activator. Thus, it prevents clot lysis in vessel walls. Several evidences prove the relationship between coronary artery disease and response to fibrinolytic therapy in patients with myocardial infarction with PAI-1 level. Opium addiction i...
متن کاملType 1 Plasminogen Activator Inhibitor
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متن کاملPlasminogen activator inhibitor type 1 deficiency.
Plasminogen activator inhibitor type 1 (PAI-1) is an important component of the coagulation system that down-regulates fibrinolysis in the circulation. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. Clear documentation of PAI-1 deficiency as a cause of a bleeding disorder has been rare. PAI-1 was initially identified in the 1980s, and the first r...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2001
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fsb2fj000393com